Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .

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PCA was used to evaluate formulations of different viscosities.


Spray congealing of selected molten mixtures was carried out using a laboratory scale spray congealer Mobile MinorNiro, Denmark. Preparation of targeted isoniazid microspheres. Chiou WL, Riegelman S. The low standard deviation values for all physical properties showed that there was excellent batch-to-batch reproducibility and absence of significant batch-to-batch variations. The Einstein coefficient depends on the geometry and orientation of the entities that make up the dispersed phase, e.

Surface plots showed that concentration of HPMC had a greater effect on the viscosity compared to temperature. The ability of PCA to differentiate the viscosity profiles of different formulations was examined.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M

Thus, the matrix became more porous less tortuous and allowed quicker release of the drug within a short period of time. Abstract The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of the drug.

Agricultural Research Service scientists are investigating using the plant-derived HPMC as a substitute for gluten hp,c making all-oat and other grain breads.

Received Jan 26; Accepted Oct Smaller particles led to a greater viscosity than larger particles. As a food additivehypromellose is an emulsifierthickening and suspending agent, and an alternative to animal gelatin. On the other hand, increase in particle size reduced the number of particles for the same HPMC concentration and reduced retardation of flow.


Air was extracted from the chamber by an exhaust fan.

Especially, the high viscosity polymers would take longer time to form a gel layer. Scores plot of the viscosity profiles of the various ternary formulations. The formulations within each group in line plot Fig. Conventional statistical method, such as analysis of variance ANOVAallows the comparison of each data point to other points at a particular temperature. Metronidazole BP gradea yellowish crystalline powder, was obtained from Sunward Pharmaceutical, Singapore.

It has been also reported that the higher K value in the case of the drug release from matrix-embedded CR tablet formulations is an indication of burst release from the formulations Impaired bioavailability of rifampicin from fixed dose combination FDC formulations with isoniazid. Degree of substitution is the average level of methoxy substitution on the cellulose chain. The release mechanism was found to be anomalous non-Fickian diffusion in all the cases. But once the required hardness was achieved, i.

Handbook of pharmaceutical excipients. Matrix technologies have often proven popular among the oral controlled drug delivery technologies because of their simplicity, ease in manufacturing, high level of reproducibility, stability of the raw materials and dosage form, and ease of scale-up and process validation.

Therefore, it is harder for longer chains to dissolve because of the high energy required for pulling them off the matrix.

Benecel™ Hydroxypropylmethylcellulose (HPMC) K4M by Ashland – Food, Beverage & Nutrition

The reason for the decrease in the release with increase in the polymer proportion might be explained as follows for water-soluble drug isoniazid. The results alluded that E15 LV did not exhibit particle-particle interaction.

Within this group, viscosities of the various formulations were similar. As mentioned earlier, at the same concentration, HPMC with a smaller particle size would be present in a larger number which would retard the flow of molten PEG.


Other research groups have reported similar results that the drug release rate decreased with increasing molecular weight for low-molecular-weight HPMCs and became independent of molecular weight for high-molecular-weight HPMCs 29 — Expert Opin Drug Deliv. Melt extrusion with poorly soluble drugs. At higher concentrations, the HPMC particles were closely packed and particle-particle interactions took place. As such, an understanding of the rheological behaviour of these melts has become increasingly important for successful process development and formulation of the desired product 12 Also, the drug has good solubility in the release medium, and hence, hpjc drug present on the surface might have o4m released quickly because of the presence of the more pores in the matrix structure.

Drugs used in the chemotherapy of tuberculosis, Mycobacterium avium complex disease, and leprosy; pp. Therefore, to ensure a higher productivity rate and a product of consistent quality, it is essential to employ an analytical tool capable of evaluating the viscosities of polymer melt suspensions.

Prentice Hall Professional Technical Reference; The influence of excipients on drug release from hydroxypropyl methylcellulose matrices. I—Formulation and in vitro evaluation. Thus, k4, must be tested and weight corrected to ensure adequate amount of dry active material are aportioned for usage. Therefore, the use of better and faster analytical method, such as PCA, can be suitable for studying the viscosity profiles of ternary melt suspensions.

Comparing the corresponding melt suspensions, those consisting of E15 LV also had the lowest viscosity. Fickian and anomalous release from swellable devices. Tablet hardness was determined for a minimum of six tablets of each batch using Monsanto standard type tablet hardness tester. Thus, higher viscosity polymers induce the formation of a thicker gel layer after hydration. Applied plastics engineering handbook.